The process by which gene families maintain high homogeneity is Concerted evolution.
2.
Ectopic gene conversion is the driving force for concerted evolution of gene families.
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Concerted evolution occurs through repeated cycles of unequal crossing over events and repeated cycles of gene transfer and conversion.
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Concerted evolution can be unbiased, in which case every version has an equal probability of being the one that replaces the others.
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In the large rDNA array, polymorphisms between rDNA repeat units are very low, indicating that rDNA tandem arrays are evolving through concerted evolution.
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Comparisons between alpha-globin, which does not have long introns, and beta-globin genes show that alpha-globin have 50 times higher concerted evolution.
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The best-known such process is the concerted evolution of genes present in many tandem copies, such as those for ribosomal RNAs or duplications and replacement of one copy by another, the copies gradually come to resemble each other much more than they would if they had been evolving independently.
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